✦ LIBER ✦

Neue β-Lactam-Antibiotika. Über die Darstellung von N-Acylderivaten der 7-Amino-ceph-3-em-4-carbonsäure. Modifikationen von Antibiotica, 6. Mitteilung [1]

✍ Scribed by R. Scartazzini; H. Bickel

Publisher: John Wiley and Sons
Year: 1972
Tongue: German
Weight: 496 KB
Volume: 55
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.19720550212

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Oxydation of 2 with iodine followed by acylation leads to β‐lactamdisulfides of type 3. Compounds 3 can be transformed into alcohols 4 by reductive alkylation with ethylenoxide and zinc/acetic acid. Compounds 4 are used as starting materials for the synthesis of N‐acylderivatives 12 of 7‐amino‐ceph‐3‐em‐4‐carboxylic acid (D).

📜 SIMILAR VOLUMES

Neue β-Lactam-Antibiotika. Über die Dars

Neue β-Lactam-Antibiotika. Über die Darstellung der 8-β-Phenylacetamido-homoceph-4-em-5-carbonsäure (1). Modifikationen von Antibiotika, 7. Mitteilung

✍ R. Scartazzini; J. Gosteli; H. Bickel; R. B. Woodward 📂 Article 📅 1972 🏛 John Wiley and Sons 🌐 German ⚖ 409 KB

## Abstract The thiazolidine β‐lactam **3** adds acrolein in a __Michael__ type reaction. The resulting 'carbinolamide **4** is converted to 8‐β‐phenylacetamido‐homoceph‐4‐em‐5‐carboxylic acid (**1**) by previously described methods.