Serially transplantable rat mammary tumor (RMT) cells are not dependent on exogenous epidermal growth factor (EGF) and insulin-like growth factor-I for continuous growth in serum-free medium. Previously, we found that conditioned medium obtained from these cells contained EGF-like mitogenic activity
Neu differentiation factor/heregulin induction by hepatocyte and keratinocyte growth factors
โ Scribed by Castagnino, Paola; Lorenzi, Matthew V; Yeh, Juddi; Breckenridge, Diane; Sakata, Hiromi; Munz, Barbara; Werner, Sabine; Bottaro, Donald P
- Book ID
- 110062707
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 474 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0950-9232
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Recently, a family of growth factors has been described that activates erbB-2 receptors. These factors, known as the neu differentiation factors (NDF) or heregulins (HRG), induce tyrosine phosphorylation of erbB-2 receptors as a result of their direct interaction with either erbB-3 or erbB-4 recepto