Networks in Systems Biology: Applications for Disease Modeling

✍ Scribed by Fabricio Alves Barbosa da Silva, Nicolas Carels, Marcelo Trindade dos Santos, Francisco José Pereira Lopes

• Publisher: Springer International Publishing;Springer
• Year: 2020
• Tongue: English
• Leaves: 381
• Series: Computational Biology 32
• Edition: 1st ed.
• Category: Library

✦ Synopsis

This book presents a range of current research topics in biological network modeling, as well as its application in studies on human hosts, pathogens, and diseases. Systems biology is a rapidly expanding field that involves the study of biological systems through the mathematical modeling and analysis of large volumes of biological data. Gathering contributions from renowned experts in the field, some of the topics discussed in depth here include networks in systems biology, the computational modeling of multidrug-resistant bacteria, and systems biology of cancer. Given its scope, the book is intended for researchers, advanced students, and practitioners of systems biology. The chapters are research-oriented, and present some of the latest findings on their respective topics.

✦ Table of Contents

Front Matter ....Pages i-x
Front Matter ....Pages 1-1
Network Medicine: Methods and Applications (Italo F. do Valle, Helder I. Nakaya)....Pages 3-18
Computational Tools for Comparing Gene Coexpression Networks (Vinícius Carvalho Jardim, Camila Castro Moreno, André Fujita)....Pages 19-30
Functional Gene Networks and Their Applications (Hong-Dong Li, Yuanfang Guan)....Pages 31-43
A Review of Artificial Neural Networks for the Prediction of Essential Proteins (Kele Belloze, Luciana Campos, Ribamar Matias, Ivair Luques, Eduardo Bezerra)....Pages 45-68
Transcriptograms: A Genome-Wide Gene Expression Analysis Method (Rita M. C. de Almeida, Lars L. S. de Souza, Diego Morais, Rodrigo J. S. Dalmolin)....Pages 69-91
A Tutorial on Sobol’ Global Sensitivity Analysis Applied to Biological Models (Michel Tosin, Adriano M. A. Côrtes, Americo Cunha)....Pages 93-118
Reaction Network Models as a Tool to Study Gene Regulation and Cell Signaling in Development and Diseases (Francisco José Pereira Lopes, Claudio Daniel Tenório de Barros, Josué Xavier de Carvalho, Fernando de Magalhães Coutinho Vieira, Cristiano N. Costa)....Pages 119-159
Front Matter ....Pages 161-161
Challenges for the Optimization of Drug Therapy in the Treatment of Cancer (Nicolas Carels, Alessandra Jordano Conforte, Carlyle Ribeiro Lima, Fabricio Alves Barbosa da Silva)....Pages 163-198
Opportunities and Challenges Provided by Boolean Modelling of Cancer Signalling Pathways (Petronela Buiga, Jean-Marc Schwartz)....Pages 199-216
Integrating Omics Data to Prioritize Target Genes in Pathogenic Bacteria (Marisa Fabiana Nicolás, Maiana de Oliveira Cerqueira e Costa, Pablo Ivan P. Ramos, Marcelo Trindade dos Santos, Ernesto Perez-Rueda, Marcelo A. Marti et al.)....Pages 217-276
Modelling Oxidative Stress Pathways (Harry Beaven, Ioly Kotta-Loizou)....Pages 277-300
Computational Modeling in Virus Infections and Virtual Screening, Docking, and Molecular Dynamics in Drug Design (Rachel Siqueira de Queiroz Simões, Mariana Simões Ferreira, Nathalia Dumas de Paula, Thamires Rocco Machado, Pedro Geraldo Pascutti)....Pages 301-337
Cellular Regulatory Network Modeling Applied to Breast Cancer (Luiz Henrique Oliveira Ferreira, Maria Clicia Stelling de Castro, Alessandra Jordano Conforte, Nicolas Carels, Fabrício Alves Barbosa da Silva)....Pages 339-365
Back Matter ....Pages 367-377

✦ Subjects

Computer Science; Computational Biology/Bioinformatics; Systems Biology; Health Informatics; Cancer Research