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Nestin expression in pancreatic endocrine and exocrine cells of mice lacking glucagon signaling

✍ Scribed by Mamdouh H. Kedees; Yelena Guz; Patricia M. Vuguin; Carlos Vargas; Lingguang Cui; Donald F. Steiner; Maureen J. Charron; Gladys Teitelman


Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
588 KB
Volume
236
Category
Article
ISSN
1058-8388

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We have examined the anti-tumor effect in nude mice caused by human pancreatic cancer cells (AsPC-1) modified to secrete IL-2 or IL-4. Loss of tumorigenicity of cytokineproducing, but not wild-type, cells was observed despite their unaltered in vitro proliferation rates; and these anti-tumor effects