Nerve-Independence of Limb Regeneration in Larval Xenopus laevis Is Correlated to the Level of fgf-2 mRNA Expression in Limb Tissues

Nerve-independence of limb regeneration

Nerve-independence of limb regeneration in larvalXenopus laevis is related to the presence of mitogenic factors in early limb tissues

✍ Filoni, Sergio; Bernardini, Sergio; Cannata, Stefano M.; Ghittoni, Raffaella 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 781 KB

Early limbs of larval Xenopus laevis can form a regeneration blastema in the absence of nerves. The nerve-independence could be due to the synthesis of neurotrophic-like factors by the limb bud cells. To test this hypothesis, two series of experiments were performed. Series A: the right hindlimbs of