Nerve growth factor specifically induces human IgG4 production
β Scribed by Hajime Kimata; Akira Yoshida; Chihiro Ishioka; Takashi Kusunoki; Susumu Hosoi; Haruki Mikawa
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 468 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0014-2980
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## Abstract Using conditioned media (CM) from phytohemagglutinin (PHA)βstimulated peripheral blood lymphocytes (PBL) we observed longβterm selective growth of Tβcells from normal human donors. This Tβcell growth was continuously dependent on addition of a factor called Tβcell growth factor (TCGF).
Monoclonal antibodies (designated XIFl and IIIG5) recognizing distinct epitopes of the human truncated nerve growth factor receptor (NGF-Rt) were used in a two-site radiometric immunosorbent assay to monitor levels of NGF-Rt in human urine as a function of age. Urine samples were collected from 70 n