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Nerve growth factor response to excitotoxic lesion of the cholinergic basal forebrain is slightly impaired in aged rats

โœ Scribed by C. A. Gericke; U. E. Lang; T. Steckler; G. Schulze; M. Bajbouj; R. Hellweg

Publisher
Springer
Year
2003
Tongue
English
Weight
155 KB
Volume
110
Category
Article
ISSN
1435-1463

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Nerve growth factor (NGF) is a potential treatment for cholinergic dysfunction associated with Alzheimer's disease (AD). In rats, NGF activates gene expression of the acetylcholine synthetic enzyme choline acetyltransferase (ChAT) and prevents age-and lesion-induced degeneration of basal forebrain (