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Nerve growth factor induces systemic hyperalgesia after thoracic burn injury in the rat

✍ Scribed by Masashi Ueda; Munetaka Hirose; Nobuyuki Takei; Takae Ibuki; Yoshihisa Naruse; Fumimasa Amaya; Yasuhiko Ibata; Masaki Tanaka


Book ID
117472873
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
103 KB
Volume
328
Category
Article
ISSN
0304-3940

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Intraspinal and behavioral events were studied in adult rats with nociceptive nerves that were undergoing collateral sprouting into adjacent denervated skin. This sprouting, which is driven by endogenous nerve growth factor (NGF), did not cause hyperalgesia. For comparison, we studied an exogenous N