Although MAG-null mice myelinate relatively normally except for subtle structural abnormalities in the periaxonal region of myelin sheaths, they develop more severe pathological changes as they age. The purpose of this study was to further define the biochemical aspects of CNS pathology caused by an
Nerve conduction abnormalities in aging mice deficient for myelin-associated glycoprotein
โ Scribed by Michael D. Weiss; Carlos A. Luciano; Richard H. Quarles
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 238 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0148-639X
- DOI
- 10.1002/mus.1159
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
When the axon of a motor neuron is sectioned and visualized by electron microscopy, a two-dimensional distribution of neurofilaments (NFs) with nonrandom spacing is revealed; this ordered arrangement implies the presence of physical interactions between the NFs. To gain insight into the molecular ba
Peripheral nerves of P0-deficient mice display a severe dysmyelinating phenotype, confirming the view that P0 mediates myelin formation and compaction. In addition to the compromised myelin organization, an elevated expression of several cell recognition molecules was described in the axon-Schwann c