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Nerve cell production in Hydra is deregulated by tumour-promoting phorbol ester

โœ Scribed by Greger, Valerie ;Berking, Stefan

Book ID
104739302
Publisher
Springer-Verlag
Year
1991
Tongue
English
Weight
300 KB
Volume
200
Category
Article
ISSN
1432-041X

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โœฆ Synopsis

The tumour-promoting phorbol ester 12-0tetradecanoylphorbol 13-acetate (TPA) interfers with nerve cell production in Hydra when applied to the animals' culture medium. Precursor cells exposed to 0.2 nM TPA during the first half of their S-phase are prevented from differentiating into nerve cells. Precursor cells which start their S-phase following a treatment with TPA give rise to nerve cells. The frequency is higher than in untreated control animals.

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