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Nephrotoxicity of hexachloro-1:3-butadiene in the male Hanover Wistar rat; correlation of minimal histopathological changes with biomarkers of renal injury

✍ Scribed by Aubrey Swain; John Turton; Cheryl Scudamore; David Maguire; Ines Pereira; Sofia Freitas; Rosemary Smyth; Michael Munday; Clare Stamp; Mitul Gandhi; Surjit Sondh; Holly Ashall; Ian Francis; Jennifer Woodfine; John Bowles; Malcolm York

Book ID: 112117723
Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 385 KB
Volume: 32
Category: Article
ISSN: 0260-437X
DOI: 10.1002/jat.1727

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## ABSTRACT Hexachloro‐1:3‐butadiene (HCBD) causes kidney injury specific to the __pars recta__ of the proximal tubule. In the present studies, injury to the nephron was characterized at 24 h following a single dose of HCBD, using a range of quantitative urinary measurements, renal histopathology a