NEPHROTOXICITY OF CYCLOSPORIN G IN RATS
β Scribed by Duncan, JanetI.; Whiting, PaulH.; Simpson, JohnG.; Thomson, AngusW.
- Book ID
- 123424864
- Publisher
- The Lancet
- Year
- 1985
- Tongue
- English
- Weight
- 299 KB
- Volume
- 326
- Category
- Article
- ISSN
- 0140-6736
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## Abstract Cyclosporin A (CsA) is the prototype of immunosuppressant drugs that have revolutionized the management of all transplantation and autoimmune diseases. Side effects of CsA mainly affecting the kidney but also observed in liver and heart, limit the therapeutic use of this drug after orga
## Abstract Cyclosporine (CsA) causes a doseβrelated decrease in renal function in experimental animals and humans. The generation of reactive oxygen species (ROS) has been implicated in CsAβinduced nephrotoxicity. It was previously shown that __Spirulina__, a blueβgreen algae, with antioxidant pro