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Nephrotoxicity and Hydration Management for Cisplatin, Carboplatin, and Ormaplatin

✍ Scribed by Terri L. Cornelison; Eddie Reed


Book ID
115615900
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
749 KB
Volume
50
Category
Article
ISSN
0090-8258

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πŸ“œ SIMILAR VOLUMES


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The nephrotoxic potentials of cisplatin and carboplatin, alone and in combination with the aminoglycoside antibiotic tobramycin, were compared in male rats. Sixty (60) male Sprague-Dawley rats were divided into six groups of ten rats each and received the following treatments: Group I, saline; group

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Background. Unlike the related drug carboplatin, cisplatin is highly nephrotoxic and must be given with vigorous intravenous hydration at a much lower dose. As the result of an accidental substitution of cisplatin for carboplatin, a 68-year-old woman received a massive overdose of cisplatin without