Nephrotoxicity and Hydration Management for Cisplatin, Carboplatin, and Ormaplatin
β Scribed by Terri L. Cornelison; Eddie Reed
- Book ID
- 115615900
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 749 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0090-8258
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The nephrotoxic potentials of cisplatin and carboplatin, alone and in combination with the aminoglycoside antibiotic tobramycin, were compared in male rats. Sixty (60) male Sprague-Dawley rats were divided into six groups of ten rats each and received the following treatments: Group I, saline; group
Background. Unlike the related drug carboplatin, cisplatin is highly nephrotoxic and must be given with vigorous intravenous hydration at a much lower dose. As the result of an accidental substitution of cisplatin for carboplatin, a 68-year-old woman received a massive overdose of cisplatin without