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Neoplastic transformation of canine embryo cells in vitro by N-methyl-N′-nitro-N-nitrosoguanidine

✍ Scribed by Johng S. Rhim; Dai K. Park; Paul Arnstein; Walter A. Nelson-Rees

Publisher
John Wiley and Sons
Year
1978
Tongue
French
Weight
632 KB
Volume
22
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

A cell line derived from a normal beagle embryo was treated in vitro with various levels of N‐methyl‐N′‐nitro‐N‐nitrosoguanidine or dimethyl sulfoxide (control). Cells treated only with the carcinogen underwent morphologic alteration in vitro, and one of these altered cell lines produced tumors sub‐cutaneously when injected into NIH nude mice. The tumorigenic transformed line formed larger cell aggregates and grew in this aggregate form when suspended in liquid growth medium above an agar base.

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