Neoplastic transformation of BALB/3T3 cells by metals and the quest for induction of a metastatic phenotype
β Scribed by Umberto Saffiotti; Federico Bertolero
- Book ID
- 112936381
- Publisher
- Humana Press Inc
- Year
- 1989
- Tongue
- English
- Weight
- 496 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0163-4984
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The metastatic phenotype of tumor cells is thought t o be induced by an aberrant signaling cascade or cascades that are different from those required for tumorigenicity. Oncogene-transfected cells with different tumorigenicities and metastatic potentials have been used t o identify such pathways and
## Abstract Benzo[a]pyreneβtransformed Balb 3T3 cells (BP3T3) exhibit βnormalβ growth controls at low concentrations of serum. Epidermal growth factor (EGF) stimulates DNA synthesis and cell division in both Balb 3T3 and BP3T3 cells at physiological concentrations. The growth response of BP3T3 cell