Neonatal Haematology: A Practical Guide

✍ Scribed by Irene Roberts, Barbara J. Bain

• Publisher: Wiley-Blackwell
• Tongue: English
• Leaves: 301
• Category: Library

✦ Synopsis

Neonatal Haematology

This unique handbook contains comprehensive coverage of neonatal haematology and aids diagnosis via high-quality images, diagnostic algorithms, case studies, and tables. With illustrations accompanying the diagnosis at each stage and clear explanations provided throughout, the book is ideal for trainees and experts alike.

Authored by two of the world’s leading haematologists, Professor Irene Roberts and Professor Barbara Bain, this book provides a depth of knowledge that is unequalled in other texts. To aid in reader comprehension, it is neatly organised by clinical problems and covers sample topics such as:

• Red cells: morphology, membrane, enzymes, and changes over the first 4 weeks of life
• Haemolytic anaemias: causes of neonatal haemolysis, diagnostic clues, and immune haemolysis (haemolytic disease of the newborn)
• Neonatal anaemia due to blood loss: causes of blood loss, diagnostic clues, feto-maternal haemorrhage, and twin-to-twin transfusion
• Haematological signs of neonatal infection: causes of neutrophil left shift, leucoerythroblastosis, and toxic granulation

Paediatric haematologists, consultant haematologists, and trainees in haematology can use the succinct, well-written content in this book as a useful helping hand during consultation. Biomedical scientists will also value the work as a laboratory reference.

✦ Table of Contents

Cover
Title Page
Copyright Page
Contents
Preface
Abbreviations
Chapter 1 The full blood count and blood film in healthy term and preterm neonates
Introduction
Brief outline of the ontogeny of haemopoiesis
Properties of fetal haemopoietic stem and progenitor cells
Red blood cell production and development in the fetus and neonate
Erythropoietin production in the fetus and neonate
Haemoglobin synthesis and red blood cell production in the fetus and newborn
Red blood cell lifespan and the red blood cell membrane in the fetus and neonate
Red blood cell metabolism in the fetus and neonate
Iron metabolism in the fetus and neonate
Normal values for red blood cell parameters in the fetus and neonate
Leucocytes in the fetus and newborn
Leucocyte production and function in the fetus and neonate
Platelets and megakaryocytes in the fetus and neonate
Developmental megakaryopoiesis and thrombopoiesis
Platelet numbers in the neonate and fetus – normal values
Neonatal platelet function
Practical problems in interpreting neonatal blood counts and films
Sample quality/artefacts
Site of sampling
Gestational age and postnatal age
Pregnancy-associated complications and mode of delivery
References
Chapter 2 Red cell disorders: anaemia, jaundice, polycythaemia and cyanosis
Neonatal anaemia
Definition and clinical significance of neonatal anaemia
Neonatal anaemia due to reduced red cell production
Neonatal anaemia due to increased red cell destruction
Neonatal anaemia due to haemoglobinopathies and other microcytic anaemias
Neonatal anaemia due to blood loss
Anaemia of prematurity
A simple diagnostic approach to neonatal anaemia
Neonatal polycythaemia
Haematological causes of cyanosis
Principles of red cell transfusion in neonates
Illustrative cases
Abbreviations used in the illustrative cases
References
Chapter 3 Neonatal infection and leucocyte disorders
Leucocyte abnormalities in neonatal systemic disease
Increases in leucocyte numbers
Neonatal infection and its differential diagnosis: clues from the blood count and blood film
Storage disorders: diagnostic clues from the blood film
Neonatal neutropenia
Definition and causes of neutropenia
Immune neutropenia
Inherited congenital or neonatal neutropenia
Haematological features of neonates with Down syndrome
Congenital leukaemia
Leukaemia and preleukaemia in neonates with Down syndrome
Acute leukaemia in neonates without Down syndrome
Juvenile myelomonocytic leukaemia and Noonan syndrome myeloproliferative disorder
Illustrative cases
Abbreviations used in the illustrative cases
References
Chapter 4 Disorders of platelets and coagulation, thrombosis and blood transfusion
Thrombocytopenia overview
Causes of neonatal thrombocytopenia: a practical classification based on age at onset
Fetal thrombocytopenia
Early-onset neonatal thrombocytopenia (presenting at <72 hours of age)
Late-onset neonatal thrombocytopenia (presenting at >72 hours of age)
Conditions leading to clinically significant thrombocytopenia in the neonate
Fetal/neonatal alloimmune thrombocytopenia
Neonatal thrombocytopenia due to maternal autoimmune disease
Thrombocytopenia due to congenital infections
Neonatal thrombocytopenia associated with chromosomal abnormalities
Inherited thrombocytopenia
Investigation of neonatal thrombocytopenia
Management of neonatal thrombocytopenia
Indications for platelet transfusion
Platelet function disorders
Inherited platelet function disorders with normal platelet counts presenting in the neonate
Thrombocytosis
Abnormalities of coagulation
Developmental haemostasis
Laboratory investigation of coagulation disorders in the neonate
Acquired coagulation abnormalities
Inherited coagulation disorders
Thrombosis
Screening tests for thrombophilia in neonates
Acquired thrombotic abnormalities
Inherited thrombotic abnormalities
General principles of neonatal platelet and plasma component transfusion
Platelet transfusion
Fresh frozen plasma
Cryoprecipitate
Prothrombin complex and recombinant factor VIIa
Illustrative cases
Abbreviations used in the illustrative cases
References
Index
EULA