Neonatal 24-hour urinary C-peptide and birth weight in infants of diabetic mothers
✍ Scribed by Hiroshi Sameshima; Masato Kamitomo; Satoshi Ibara; Shoko Kajiya; Motoaki Kai; Tsuyomu Ikenoue
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 78 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1057-0802
No coin nor oath required. For personal study only.
✦ Synopsis
Objective:
Our purpose was to investigate the relationship between the birth weights and 24-h urinary c-peptide in infants of diabetic mothers.
Methods:
Sixty pregnancies with gestational diabetes mellitus (dm) were enrolled. neonatal urine was collected for the first and second 24 h for measuring c-peptide. birth weights were classified into 3 categories according to the japanese standard curves; heavy-for-date (hfd), appropriate-for-date (afd), and light-for-date (lfd). unpaired t-test was used for comparison of 24-h urinary c-peptide in the 3 birth weight categories, with p-value <0.05. there were 7 hfd, 47 afd, and 6 lfd infants. birth weight averaged 3.9+/-0.7, 3.0+/-0.4, and 2.3+/-0.3 kg, respectively.
Results:
Insulin concentrations of the umbilical artery were significantly higher in hfd than in afd, and significantly higher in afd than in lfd (49.5+/-45.1, 16.8+/-15.2, and 6.3+/-6.1 microu/ml). during the first 24 h, urinary c-peptide was significantly higher in hfd than in afd (2.73+/-1.52 vs. 0.76+/-0.81 microg/day), and significantly higher in afd than in lfd (0.27+/-0.27). on the second day, there was no longer statistical significance.
Conclusions:
Measurement of 24-h urinary c-peptide revealed that, among infants of diabetic mothers, hfd infants continue to secrete more insulin than afd and lfd infants for the first 24 h.