Neobacillamide A, a Novel Thiazole-Containing Alkaloid from the Marine Bacterium Bacillus vallismortis C89, Associated with South China Sea Sponge Dysidea avara

✍ Scribed by Lu-Lu Yu; Zhen-Yu Li; Chong-Sheng Peng; Zhi-Yong Li; Yue-Wei Guo

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: German
• Weight: 159 KB
• Volume: 92
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200800349

✦ Synopsis

Abstract

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A novel thiazole alkaloid, neobacillamide A (1), together with a known related one, bacillamide C (4), was isolated from the bacterium Bacillus vallismortis C89, associated with the South China Sea sponge Dysidea avara. The structure of the new compound was elucidated on the basis of its spectroscopic data. A plausible biosynthetic pathway is proposed. Neobacillamide A represents the first example of a thiazole‐carboxamide bearing a 2‐phenylethylamine moiety.