## Abstract ## BACKGROUND. The objective of the current study was to determine the histologic and molecular changes that occurred in patients with highβrisk, localized prostate cancer (PCa) after neoadjuvant docetaxel chemotherapy. ## METHODS. Patients who had locally advanced PCa (serum preoper
Neoadjuvant strategies for the treatment of locally advanced esophageal cancer
β Scribed by John R. Hyngstrom; Mitchell C. Posner
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 85 KB
- Volume
- 101
- Category
- Article
- ISSN
- 0022-4790
No coin nor oath required. For personal study only.
β¦ Synopsis
Abstract
Patients with locally advanced esophageal carcinoma have consistently poor survival following surgery with associated high systemic and localβregional failure rates. Neoadjuvant therapeutic strategies have been employed in an attempt to improve outcome with variable success. Randomized trials of either neoadjuvant chemotherapy or chemoradiotherapy have shown conflicting results regarding survival and localβregional control. Future efforts should focus on identifying novel agents and targets to improve therapeutic efficacy. J. Surg. Oncol. 2010; 101:299β304. Β© 2010 WileyβLiss, Inc.
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