NEM Tubulin Inhibits Microtubule Minus End Assembly by a Reversible Capping Mechanism †

Tubulin-colchicine complex (TC) inhibits

Tubulin-colchicine complex (TC) inhibits microtubule depolymerization by a capping reaction exerted preferentially at the minus end

✍ Lawrence G. Bergen; Gary G. Borisy 📂 Article 📅 1986 🏛 John Wiley and Sons 🌐 English ⚖ 444 KB

The effects of colchicine and tubulin-colchicine complex (TC) on microtubule depolymerization were studied using the axoneme-subunit system described previously [Bergen LG, Borisy GG; J Cell Biol 84:141-150, 1980]. This system allows the independent analysis of the polymerization kinetics at both th