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Neighboring base identity affects N-ethyl-N-nitrosourea-induced mutagenesis in Escherichia coli

✍ Scribed by Zhehong Cai; Douglas Fix

Book ID
114070655
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
139 KB
Volume
508
Category
Article
ISSN
0027-5107

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DNA sequencing was used to determine the specific types of DNA base changes induced following in vivo exposure of Escherichia coli to the ethylating agent N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG) and the hydroxyethylating agent 1-(2-hydroxyethyl)-1-nitrosourea (HENU) using the xanthine guanine pho