Negative result in search for human alpha-dystrobrevin deficiency

Comparison of in vitro micronucleus and

Comparison of in vitro micronucleus and gene mutation assay results for p53-competent versus p53-deficient human lymphoblastoid cells

✍ Masamitsu Honma; Makoto Hayashi 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 285 KB 👁 1 views

## Abstract The high frequency of false or irrelevant positive results in in vitro mammalian cell genotoxicity tests is a critical concern for regulators. Here, we tested whether such results may be due to the mammalian cells used in the tests being deficient in p53, which is involved in the mainte