๐”– Bobbio Scriptorium
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Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21

โœ Scribed by Sheedy, Frederick J; Palsson-McDermott, Eva; Hennessy, Elizabeth J; Martin, Cara; O'Leary, John J; Ruan, Qingguo; Johnson, Derek S; Chen, Youhai; O'Neill, Luke A J


Book ID
109920843
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
587 KB
Volume
11
Category
Article
ISSN
1529-2908

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Phosphatase and tensin homolog (PTEN) is a regulator of phosphoinositide 3-kinase signaling and an important tumor suppressor mutated/deleted in human cancers. PTEN deletion in the liver leads to insulin resistance, steatosis, inflammation, and cancer. We recently demonstrated that unsaturated fatty