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Negative regulation of diacylglycerol kinase θ mediates adenosine-dependent hepatocyte preconditioning

✍ Scribed by Baldanzi, G; Alchera, E; Imarisio, C; Gaggianesi, M; Dal Ponte, C; Nitti, M; Domenicotti, C; van Blitterswijk, W J; Albano, E; Graziani, A

Book ID: 109841262
Publisher: Nature Publishing Group
Year: 2010
Tongue: English
Weight: 702 KB
Volume: 17
Category: Article
ISSN: 1350-9047
DOI: 10.1038/cdd.2009.210

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The role of diacylglycerol (DAG) in hormonal induction of S phase was investigated in primary cultures of rat hepatocytes. In this model, several agonists that bind to G protein-coupled receptors act as comitogens when added to the cells soon after plating (i.e., in Go/early Gl phase), while the cel