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Negative Regulation of Cytokines Inhibition of the Production of Interleukin-1 and Tumor Necrosis Factor

✍ Scribed by PETER RALPH; ILONA NAKOINZ; ADAM SAMPSON-JOHANNES


Book ID
119865611
Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
468 KB
Volume
628
Category
Article
ISSN
0890-6564

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Interleukin-18 (IL-18) is not only a co-stimulus for the induction of interferon-gamma but also has direct proinflammatory effects by inducing tumor necrosis factor-alpha (TNF-alpha), IL-1, IL-8 and IL-6. However, the cascade of events leading to induction of cytokines by IL-18 is unclear. The aim o