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Negative ion electrospray ionization tandem mass spectrometry in the structural characterization of penicillins

✍ Scribed by Susanna Rabbolini; Elisabetta Verardo; Marco Da Col; Anna Maria Gioacchini; Pietro Traldi

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 116 KB
Volume: 12
Category: Article
ISSN: 0951-4198
DOI: 10.1002/(sici)1097-0231(19981130)12:22<1820::aid-rcm387>3.0.co;2-c

No coin nor oath required. For personal study only.

✦ Synopsis

The mass spectrometry (MS) behaviour of ten commercially available penicillins has been studied by means of electrospray and multiple-stage MS/MS experiments performed using an ion trap instrument. For all the examined compounds negative ions are produced under ESI conditions, with a yield two or three orders of magnitude higher than that observed for positive ions. MS n experiments indicate the occurrence of a fragmentation pathway related to the b-lactam ring, different from that usually described for positive ions of these compounds, and provide structural information on both the b-lactam ring and the side chains.

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