Negative ion chemical ionization gas chromatography/mass spectrometry and gas chromatography/tandem mass spectrometry of prostanoid pentafluorobenzyl ester/methoxime/trimethylsilyl ether derivatives

✍ Scribed by Horst Schweer; Hannsjörg W. Seyberth; Claus O. Meese; Otto Fürst

• Publisher: John Wiley and Sons
• Year: 1988
• Tongue: English
• Weight: 526 KB
• Volume: 15
• Category: Article
• ISSN: 1076-5174
• DOI: 10.1002/bms.1200150305

✦ Synopsis

Negative ion chemical ionization mass spectra of prostaglandin F,,, prostaglandin EZ, prostaglandin D2, 6-0x0prostaglandin F,,, 2,3-dinor-6-oxo-prostaglandin F,, , thromboxane B,, 2,3-dinor-thromboxane B,, and 1 l-dehydrothromboxane B2 pentafluorobenzyl ester (PFB)/methoxime/trimethylsilyl ether derivatives are presented. Collisionally activated decomposition mass spectra of the [M -PFBJ-ions at collision energies of 8-24 eV and argon collision gas pressures of 1-2 mTorr almost show only fragmentation of trimethylsilanol, (CH,),Si=CHOH, (CH,),Si=CH, and methanol whereas, except for carbon dioxide loss, only few low-intensity fragments from the carbon skeleton of the prostanoids are observed.