Negative chronotropic effect of a novel class III antiarrhythmic drug, UK-68,798, devoid of β-blocking action on isolated guinea-pig atria

Effects of altered extracellular potassi

Effects of altered extracellular potassium and pacing cycle length on the class III antiarrhythmic actions of dofetilide (UK-68,798) in guinea-pig papillary muscle

✍ Tao Yang; Pål M. Tande; David A. Lathrop; Helge Refsum 📂 Article 📅 1992 🏛 Springer US 🌐 English ⚖ 713 KB

The effects of altered extracellular K+ concentrations ([K+]o) and pacing cycle lengths (CLs) on the electrophysiological actions of dofetilide (UK-68,798), a potent class III antiarrhythmic agent, were examined in isolated guinea-pig ventricular papillary muscle. At a normal [K+]o (4 mM) and at CL