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Necrotizing fasciitis as a late complication of multimodal treatment for locally advanced head and neck cancer: A case report

✍ Scribed by Fernando C. Maluf; William N. William; Jr.; Otelo Rigato; Antonio D. Menon; Orlando Parise; Jr.; Marcos F. L. Docema

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 404 KB
Volume: 29
Category: Article
ISSN: 1043-3074
DOI: 10.1002/hed.20558

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background.

Late complications of novel organ preservation multimodal protocols for the treatment of locally advanced head and neck cancer may be underreported in the literature.

Methods and Results.

We present the case of a 64‐year‐old man with T4 N0 M0 squamous cell carcinoma of the oropharynx, who enrolled on an organ‐preservation protocol at our institution. He received 2 cycles of neoadjuvant chemotherapy with capecitabine, docetaxel, and carboplatin, followed by 2 more identical cycles given concurrently with radiotherapy. Nine months later, he was admitted to the hospital with Streptococcus pyogenes necrotizing fasciitis of the cervical region, leading to rapidly progressive septic shock.

Conclusions.

Severe infectious complications of chemoradiation for locally advanced head and neck cancer may occur months after completion of treatment. The recognition of these late side effects is crucial so as to accurately ascertain the long‐term morbidity and benefits of organ‐preservation protocols in this setting. © 2007 Wiley Periodicals, Inc. Head Neck, 2007

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