Near-quantitative conversion of labelled acids to esters by modified hassner esterification. Synthesis of labelled triglycerides

✍ Scribed by Tomáš Elbert

• Book ID: 102371007
• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: French
• Weight: 369 KB
• Volume: 27
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.2580270115

✦ Synopsis

The modification of the reaction conditions of Hassner esterification -DCC/4-dimethylaminopyridine methodmerely the gradual addition of DCC to the reaction mixtureeliminated the unwanted side reaction -N-acyl-N,N--dicyclohexylurea formation and thus improved the conversion of the acid to the desired ester. Glycerol tri[U-l4C] palmitate, glycerol tri[U-14CJoleate and glycerol tri[9,10 Hlstearate with molar activities greater than 18 00 M B q . n ? m ~l -~ were prepared with preparative radiochemical yields about 86-92 %.