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Near-haploid karyotype in a squamous cell lung carcinoma

✍ Scribed by Valérie Drouin; Franck Viguié; Bernard Debesse

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
337 KB
Volume
7
Category
Article
ISSN
1045-2257

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✦ Synopsis

Abstract

Cytogenetic analysis of a squamous cell lung carcinoma revealed a near‐haploid karyotype with 27 chromosomes, in both primary cultures and an established cell line. The only chromosomes with two homologs present were chromosomes X, 5, 7, and 22. The two X chromosomes were early and late replicating, respectively. No structural rearrangements could be detected. In vitro, the clone evolved by duplication towards hyperdiploidy with 54 chromosomes. © 1993 Wiley‐Liss, Inc.

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