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Nd:YAG laser-induced hyperthermia in a mouse tumor model

✍ Scribed by Stephen M. Waldow; Paul R. Morrison; Leonard I. Grossweiner

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 436 KB
Volume: 8
Category: Article
ISSN: 0196-8092
DOI: 10.1002/lsm.1900080510

No coin nor oath required. For personal study only.

✦ Synopsis

Hyperthermic tumor response induced by 1,064-nm radiation from an Nd:YAG laser was investigated in DBA/2J female mice bearing the SMT-F mammary carcinoma. The measured temperature-depth profiles indicate that hyperthermic temperatures can be achieved in tumors ranging from 3 to 8 mm thick at power inputs on the order of 1 W. For small tumors, a 5-week complete response rate exceeding 50% required 45 minutes at 45.0 degrees C. Control of large tumors (6-8 mm thick) was not achieved. The observed tumor response rates are consistent with semiempirical time-temperature relations based on other heating modalities.

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