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NCX4016: a novel antithrombotic agent

✍ Scribed by P Gresele; S Momi; A.M Mezzasoma


Book ID
119631515
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
198 KB
Volume
35
Category
Article
ISSN
1590-8658

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Derivatization of the octadecathymidylate derivative 18 (T18 ODN) containing a free amine function with sulfo-SIAB@ gave the corresponding iodoacetyl ODN 21. Conjugation of the latter with the thiol-containing pentasaccharide 17c gave pentasaccharide-ODN conjugate 111, which exhibited anti-Xa and an