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NBS1 657del5 mutation may contribute only to a limited fraction of breast cancer cases in Russia

✍ Scribed by Konstantin G. Buslov; Aglaya G. Iyevleva; Elena V. Chekmariova; Evgeny N. Suspitsin; Alexandr V. Togo; Ekatherina Sh. Kuligina; Anna P. Sokolenko; Dmitry E. Matsko; Elena A. Turkevich; Yulia R. Lazareva; Oleg L. Chagunava; Elena M. Bit-Sava; Vladimir F. Semiglazov; Peter Devilee; Cees Cornelisse; Kaido P. Hanson; Evgeny N. Imyanitov


Publisher
John Wiley and Sons
Year
2005
Tongue
French
Weight
102 KB
Volume
114
Category
Article
ISSN
0020-7136

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NBS1 657del5 mutation may contribute onl
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## Abstract The gene for Nijmegen chromosomal breakage syndrome (__NBS1__) plays a role in a variety of processes protecting chromosomal stability. Recently, it was suggested in a Polish case‐control study that the founder hypomorphic mutation in __NBS1__, 657del5, which occurs in approximately 0.5

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## Abstract Recent studies have demonstrated that heterozygous carriers of the __NBS1__ 657del5 mutation have an increased risk for familial and bilateral breast cancer, but similar studies in consecutive breast cancer patients were inconclusive. Here, in a study of 562 nonselected breast cancer pa