## Abstract The gene for Nijmegen chromosomal breakage syndrome (__NBS1__) plays a role in a variety of processes protecting chromosomal stability. Recently, it was suggested in a Polish caseβcontrol study that the founder hypomorphic mutation in __NBS1__, 657del5, which occurs in approximately 0.5
NBS1 657del5 mutation may contribute only to a limited fraction of breast cancer cases in Russia
β Scribed by Konstantin G. Buslov; Aglaya G. Iyevleva; Elena V. Chekmariova; Evgeny N. Suspitsin; Alexandr V. Togo; Ekatherina Sh. Kuligina; Anna P. Sokolenko; Dmitry E. Matsko; Elena A. Turkevich; Yulia R. Lazareva; Oleg L. Chagunava; Elena M. Bit-Sava; Vladimir F. Semiglazov; Peter Devilee; Cees Cornelisse; Kaido P. Hanson; Evgeny N. Imyanitov
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- French
- Weight
- 102 KB
- Volume
- 114
- Category
- Article
- ISSN
- 0020-7136
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## Abstract Recent studies have demonstrated that heterozygous carriers of the __NBS1__ 657del5 mutation have an increased risk for familial and bilateral breast cancer, but similar studies in consecutive breast cancer patients were inconclusive. Here, in a study of 562 nonselected breast cancer pa