Navigator-triggered oxygen-enhanced MRI with simultaneous cardiac and respiratory synchronization for the assessment of interstitial lung disease.
✍ Scribed by Francesco Molinari; Monika Eichinger; Frank Risse; Christian Plathow; Michael Puderbach; Sebastian Ley; Felix Herth; Lorenzo Bonomo; Hans-Ulrich Kauczor; Christian Fink
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 372 KB
- Volume
- 26
- Category
- Article
- ISSN
- 1053-1807
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Purpose
To evaluate an optimized method for oxygen‐enhanced MRI of the lung, using simultaneous electrocardiograph (ECG) and navigator triggering. To correlate oxygen‐enhanced MRI with lung function tests assessing alveolar‐capillary gas exchange.
Materials and Methods
A total of 12 healthy volunteers (aged 20–32 years) and 10 patients (aged 37–87 years) with interstitial lung diseases (ILD) underwent oxygen‐enhanced MRI and pulmonary functional tests (PFTs) assessing alveolar‐capillary gas exchange. The paradigm room‐air–oxygen–room‐air was acquired with a nonselective inversion‐recovery half‐Fourier single‐shot turbo spin‐echo sequence (inversion time = 1200 msec; acquisition time = 134.5 msec; slice thickness = 20 mm; matrix size = 128 × 128), using simultaneous double triggering (navigator plus ECG trigger). Cross‐correlation was performed in regions of interest (ROIs) encompassing both lungs. The number of oxygen‐activated pixels over the total number of pixels in the ROIs (OAP%) of volunteers and patients was compared. OAP%s were correlated with PFTs.
Results
The mean OAP% of patients was significantly lower than that of volunteers (36.7 vs. 81.7, P = 0.001). OAP% correlated with the transfer lung factor for carbon monoxide (Tlco) (r = 0.64; P = 0.002), the transfer coefficient (Kco) (r = 0.75; P = 0.001), the arterial partial pressure (r = 0.77; P < 0.001), and the saturation (r = 0.70; P < 0.001) of oxygen.
Conclusion
Navigator‐triggered oxygen‐enhanced MRI of the lung may have a potential role in the quantitative assessment of lung function in ILD. J. Magn. Reson. Imaging 2007. © 2007 Wiley‐Liss, Inc.