✦ LIBER ✦
Naturally-occurring double-stranded RNA and immune responses. IV. Influence of molecular size on antigenicity and adjuvant activity
✍ Scribed by Pamela M. Butlin; P. G. Cunnington
- Book ID
- 102824752
- Publisher
- John Wiley and Sons
- Year
- 1976
- Tongue
- English
- Weight
- 616 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0014-2980
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
The immunological properties of a naturally‐occurring double‐stranded ribonucleic acid (ds‐RNA), obtained from a mycophage of Penicillium chrysogenum, have been studied in relation to molecular size. Materials of reduced size, as reflected by molecular weight measurements, produced by ultrasonication of native ds‐RNA, exhibited progressively lowered ability to induce an anti‐ds‐RNA response in mice. Adjuvant and immunosuppressive activities were of similar magnitude in both high and low molecular weight fractions. Evidence was also obtained of increased toxicity in materials of reduced size.