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Naturally occurring cytotoxic anti-tumour antibodies in sera of congenitally athymic (nude) mice

โœ Scribed by MARTIN, W. JOHN; MARTIN, SUE ELLEN


Book ID
109690651
Publisher
Nature Publishing Group
Year
1974
Tongue
English
Weight
250 KB
Volume
249
Category
Article
ISSN
0028-0836

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The rate of catabolism of a radiolabelled monoclonal anti-CEA antibody has been compared with that of control IgG1 in control nude mice and in mice with CEA producing xenografts and antigen negative xenografts. The rate of catabolism of antibody, but not of IgG, was increased 3-4 fold in mice with x