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Natural variation of HIV-1 group M integrase: Implications for a new class of antiretroviral inhibitors

✍ Scribed by Soo-Yon Rhee; Tommy F Liu; Mark Kiuchi; Rafael Zioni; Robert J Gifford; Susan P Holmes; Robert W Shafer


Book ID
119907863
Publisher
BioMed Central
Year
2008
Tongue
English
Weight
308 KB
Volume
5
Category
Article
ISSN
1742-4690

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✍ Karl Maurer; Ann H. Tang; George L. Kenyon; Andrew D. Leavitt πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 English βš– 207 KB

Integration of a DNA copy of the HIV-1 genome is required for viral replication and pathogenicity, and this highly specific molecular process is mediated by the virus-encoded integrase protein. The requirement for integration, combined with the lack of a known analogous process in mammalian cells, m