Natural killer augmentation in systemic lupus erythematosus via a soluble mediator derived from human lymphocytes
✍ Scribed by Donald B. Kaufman
- Publisher
- John Wiley and Sons
- Year
- 1982
- Tongue
- English
- Weight
- 551 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0004-3591
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✦ Synopsis
Abstract
Seventeen patients with diagnosed systemic lupus erythematosus were studied for natural killer activity and the ability of a human soluble immune‐response factor to modify this activity. Defective natural killer activity was found in patients with systemic lupus erythematosus regardless of the stage of disease, medication, or organ system involvement (24.6% versus 47.8% cytotoxicity). After treatment with the immune‐response factor, the natural killer activity increased in all patients, with a mean of 47.3% compared with 24.6% before treatment. This product has other immunologic activities and was shown to be free of interferon. The mechanism of action is not yet known, but such an immune‐response factor has potential use in the treatment of systemic lupus erythematosus.