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Natural History and Life Expectancy in Severe Alpha1-Antitrypsin Deficiency, Pi Z

✍ Scribed by Larsson, Christer

Book ID
114691431
Publisher
Wiley (Blackwell Publishing)
Year
2009
Weight
524 KB
Volume
204
Category
Article
ISSN
0001-6101

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Alpha-1 antitrypsin (AAT; HUGO symbol, SERPINA1) is one of the major serine protease inhibitors (serpins) in human plasma. Deficiency of AAT is a recognised risk factor for chronic obstructive pulmonary disease (COPD), attributed to uninhibited neutrophil elastase released into the lung tissue durin