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Nasopharyngeal carcinoma—Review of the molecular mechanisms of tumorigenesis

✍ Scribed by Josephine Chou; Yu-Ching Lin; Jae Kim; Liang You; Zhidong Xu; Biao He; David M. Jablons

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
406 KB
Volume
30
Category
Article
ISSN
1043-3074

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✦ Synopsis

Abstract

Nasopharyngeal carcinoma (NPC) is a head and neck cancer rare throughout most of the world but common in certain geographic areas, such as southern Asia. While environmental factors and genetic susceptibility play important roles in NPC pathogenesis, the Epstein–Barr virus in particular has been implicated in the molecular abnormalities leading to NPC. There is upregulation of cellular proliferation pathways such as the Akt pathway, mitogen‐activated protein kinases, and the Wnt pathway. Cell adhesion is compromised due to abnormal E‐cadherin and β‐catenin function. Aberrations in cell cycle are due to dysregulation of factors such as p16, cyclin D1, and cyclin E. Anti‐apoptotic mechanisms are also upregulated. There are multiple abnormalities unique to NPC that are potential targets for novel treatments. © 2008 Wiley Periodicals, Inc. Head Neck, 2008

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