Nasopharyngeal carcinoma—a retrospective review of patients less than thirty years of age: A report from childrens cancer study group
✍ Scribed by R. Derek T. Jenkin; James R. Anderson; Berta Jereb; John C. Thompson; Alan Pyesmany; William M. Wara; Denman Hammond
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- English
- Weight
- 665 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0008-543X
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✦ Synopsis
Data from 119 patients with nasopharyngeal carcinoma who were under 30 years of age were retrospectively analyzed by the investigators of the Childrens Cancer Study Group. The overall five-year survival and relapse-free survival rates from diagnosis were 51 and 36%, respectively. When the tumor was confined to the nasopharynx (T1 + T2, 41 patients), the five-year survival was 75%. No significant correlation was found between survival or local recurrence and the radiation dose to the primary site. The five-year survival from relapse was 37% for 21 reirradiated patients with local and/or regional relapse compared with 11% for 45 patients with other forms of relapse. It is concluded that the optimal radiation dose for tumor eradication in young patients is not known.
Cancer 47:360-366, 1981.
N NORTH AMERICA the age-incidence curve for I nasopharyngeal carcinoma is bimodal with a first peak incidence occurring between age 15 and 25.'" For these patients, the etiology of the disease may be different than that for those who are diagnosed later in life.1*11*12 Certainly the disease in this age group is associated with prior infection with the EB virus,"" varies geographically,2*5,'0,12 and occurs more often as lymphoepithelioma or poorly differentiated epidermoid carcinoma.5*12.21