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Naphthazarin and methylnaphthazarin cause vascular dysfunction by impairment of endothelium-derived nitric oxide and increased superoxide anion generation

✍ Scribed by Jaw-Jou Kang; Po-Jung Lee; Yen-Ju Chen; Chen-Chen Lee; Chin-How Li; Hui-Wen Cheng; Yu-Wen Cheng

Book ID: 116919297
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 202 KB
Volume: 20
Category: Article
ISSN: 0887-2333
DOI: 10.1016/j.tiv.2005.05.006

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## Abstract Proliferative modification of vascular smooth muscle cell (vSMC) and impaired bioavailability of nitric oxide (NO) have both been proposed among the mechanisms linking diabetes and atherosclerosis. However, diabetes induced modifications in phenotype and nitric oxide synthase(s) (NOS) e