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Naphthalene-catalysed lithiation of phenone imines in the presence of carbonyl compounds: preparation of 1,2-aminoalcohols

✍ Scribed by David Guijarro; Miguel Yus

Publisher
Elsevier Science
Year
1993
Tongue
French
Weight
529 KB
Volume
49
Category
Article
ISSN
0040-4020

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✦ Synopsis

The lithiation of different phenone imines 1 with an excess of lithium powder and a catalytic amount (8 mol %) of naphthalene in the presence of several carbonyl compounds 2 in tetrahydmftuan at temperahnes ranging between -78 and 2OT leads, after hydrolysis with water, to the cotresponding l&uainoalcohols 3 in moderate yields.

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