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Nap1 Regulates Dictyostelium Cell Motility and Adhesion through SCAR-Dependent and -Independent Pathways

✍ Scribed by Neysi Ibarra; Simone L. Blagg; Francisca Vazquez; Robert H. Insall

Book ID: 113559963
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 278 KB
Volume: 16
Category: Article
ISSN: 0960-9822
DOI: 10.1016/j.cub.2006.02.068

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## Abstract Notch signaling is a potential therapeutic target for various solid and hematopoietic malignancies. We have recently shown that downregulation of Notch‐1 expression has significant anti‐neoplastic activity in pre‐clinical models. However, the mechanisms through which Notch modulation ma