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Nanoparticles in Biology and Medicine || Preparation of siRNA-Encapsulated PLGA Nanoparticles for Sustained Release of siRNA and Evaluation of Encapsulation Efficiency

โœ Scribed by Soloviev, Mikhail

Book ID
120362762
Publisher
Humana Press
Year
2012
Weight
331 KB
Category
Article
ISBN
161779953X

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โœ Gunilla B. Jacobson; Emilio Gonzalez-Gonzalez; Ryan Spitler; Rajesh Shinde; Devi ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 441 KB

A key challenge in developing RNAi-based therapeutics is efficient delivery of functional short interfering RNA (siRNA) to target cells. To address this need, we have used a supercritical CO(2) process to incorporate siRNA in biodegradable polymer nanoparticles (NPs) for in vivo sustained release. B