## Abstract We describe the rational design of a novel, highly potent inhibitor of type II dehydroquinase, the dicarboxylate **6**. The incorporation of a carboxylate at the 3‐position mimics the putative enolate intermediate in the reaction mechanism, and allows a potential electrostatic binding i
✦ LIBER ✦
Nanomolar Inhibition of Type II Dehydroquinase Based on the Enolate Reaction Mechanism
✍ Scribed by Miguel D. Toscano; Richard J. Payne; Akira Chiba; Olivier Kerbarh; Chris Abell
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 276 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1860-7179
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Bisphenol A-based benzoxazine that contained oligomers (oligo-Ba) was prepared from bisphenol A, formaline, and aniline. Curing reaction of oligo-Ba with bisoxazoline and the properties of the cured resin were investigated. Consequently, the ring-opening reaction of benzoxazine ring occurred, and th