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Naloxone-reversible antidiarrheal effects of enkephalinase inhibitors

✍ Scribed by H. Marçais-Collado; G. Uchida; J. Costentin; J.-C. Schwartz; J.-M. Lecomte

Book ID
115880913
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
615 KB
Volume
144
Category
Article
ISSN
0014-2999

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✍ S. J. Livingston; R. D. E. Sewell; K. F. Rooney; H. J. Smith 📂 Article 📅 1988 🏛 Springer 🌐 English ⚖ 477 KB

The effects of 60 min pretreatment with the enkephalinase inhibitor acetorphan were assessed on naloxone-precipitated (2.5 mg/kg IP) abstinence in chronically morphinized rats. In addition, the antinociceptive activity of the compound was investigated in mice. Intraperitoneal injection (50 mg/kg) in