Naloxone inhibits clomipramine in mouse forced swimming test
✍ Scribed by Jean-Louis Devoize; François Rigal; Alain Eschalier; Jean-François Trolese
- Book ID
- 115877175
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- English
- Weight
- 173 KB
- Volume
- 78
- Category
- Article
- ISSN
- 0014-2999
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Tricyclic antidepressant-morphine interactions have been extensively studied on pain tests but less often on tests predictive of antidepressant activity. The effects of clomipramine (CMI) and morphine were tested on the forced swimming test in mice after pretreatment with CMI, morphine or saline. Li
The influence of naloxone on the effects of several antidepressant drugs, atropine and caffeine was studied in the forced swimming test in mice. Naloxone itself has no effect in this test, but significantly reduces that of two tricyclic antidepressants, clomipramine (20 and 30 mg/kg) and desipramine