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Naloxone effects on schedule-controlled behavior in morphine-pelleted rats

โœ Scribed by Alice M. Young; Travis Thompson

Publisher
Springer
Year
1979
Tongue
English
Weight
788 KB
Volume
62
Category
Article
ISSN
0033-3158

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โœฆ Synopsis

The effects of morphine pellet implantation and naloxone administration were examined in rats lever pressing under inter-response time schedules of food presentation. Subcutaneous implantation of a morphine pellet initially decreased lever-pressing rates. Tolerance to this effect developed within 3-4days. Naloxone (0.25-1.0 mg/kg) decreased response rates in morphine-pelleted rats in a dose-dependent and time-dependent manner. All doses of naloxone severely decreased rates of lever pressing on days four to nine post-pellet. This rate-decreasing effect persisted 7-17days for 0.25mg/kg naloxone, 9-22days for 0.50 mg/kg, and 13-28 days for 1.0 mg/kg. Decreases in response rate were due to an increased frequency of long pauses and not to marked shifts in the temporal patterning of those lever presses that did occur. Changes in response rate after naloxone were accompanied by body weight loss. Area values summarizing the naloxone-induced changes in response rate or body weight over time after pellet implantation increased as a function of naloxone dose. Naloxone (0.25-1.0mg/kg) did not alter performance by placebopelleted rats.

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